Watch Closely (2)pentobarbital will lessen the level or impact of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Powerful CYP3A4 inducers may possibly decrease suvorexant efficacy; if enhanced suvorexant dose necessary, will not exceed twenty mg/daypentobarbital will reduce the extent or outcome of bexaroten